Bromelain

- Helps relieve minor pain, swelling and inflammation
- Provides 500 mg of bromelain from pineapple stems per capsule
- Supports healthy digestion by improving the breakdown of food proteins
- Provides the clinical dose used in controlled trials to support musculoskeletal health.
- Bromelain is well absorbed and retains its enzymatic activity, which gives it systematic anti-inflammatory effects.
Bromelain, found in pineapple stems, is a combination of several proteolytic enzymes classified as cysteine ​​or thiol proteinases. Bromelain's long history as a digestive aid is partly attributed to its ability to digest proteins over a wide pH range. However, it has also been shown to stimulate pancreatic enzyme production and improve epithelial integrity in experimental models.1
In addition to its function as a digestive enzyme, bromelain is absorbed in the digestive tract and retains its enzymatic activity in the blood. Among its many enzymatic effects, bromelain has been shown to be a potent anti-inflammatory agent, reducing levels of inflammatory signals, such as tumor necrosis factor (TNF) and nuclear factor kappa B (NF-kappaB).
The anti-inflammatory, fibrinolytic and analgesic effects of bromelain are also responsible for many of its beneficial effects on the musculoskeletal system. In an open trial, bromelain supplementation was shown to reduce acute knee pain as well as stiffness and function, with a dose-dependent effect. In another clinical trial for mild/moderate knee osteoarthritis, bromelain had similar effectiveness to standard treatment after four weeks. Faster recovery and reduction in pain and swelling following several types of minor trauma have also been reported with bromelain.