- Signs and symptoms of vitamin B12 deficiency include fatigue, cognitive decline, mood changes, peripheral neuropathy, restless legs syndrome, macrocytic anemia, and hyperhomocysteinemia
- Vitamin B12 supplementation can be found in several forms, although methylcobalamin is the form primarily found in plasma and cerebrospinal fluid
- Methylcobalamin has been specifically studied for its ability to improve peripheral neuropathy, multiple sclerosis, low mood and cognitive decline
B vitamins are necessary cofactors for enzymatic reactions and most physiological functions. Vitamin B12 in particular plays an essential role in maintaining nervous system function. Signs and symptoms of B12 deficiency may include fatigue, cognitive decline, mood changes, peripheral neuropathy, restless legs syndrome, macrocytic anemia, and hyperhomocysteinemia.
This essential vitamin is found primarily in animal meats, meaning vegans and vegetarians are at particular risk of developing suboptimal levels. However, various stressors such as digestive diseases and pharmaceutical medications can also lead to vitamin B12 deficiency in the body. In fact, a large-scale research trial found that nearly 40% of the general population may have suboptimal serum B12 levels. For these many reasons, vitamin B12 supplementation may be necessary in certain populations.
Vitamin B12 can be found in several forms, including cyanocobalamin, hydroxocobalamin, adenosylcobalamin, and methylcobalamin. The latter two forms are generally preferred for supplementation because they are the cofactor forms used in enzymatic reactions in the body. Adenosylcobalamin is the major form in cellular tissues while methylcobalamin is predominant in plasma and cerebrospinal fluid.
Specifically, methylcobalamin has been studied to protect the brain and neurological tissues in multiple sclerosis, cognitive diseases, low mood, and peripheral neuropathy. It has also been shown to normalize circadian rhythms and improve sleep parameters.
Cyto-B12 offers liquid delivery of highly bioavailable vitamin B12 in the form of methylcobalamin. Each drop provides 500mcg to offer a targeted and variable dosage in a natural blueberry flavor.
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