I 3 C - Indole-3-Carbinol

- Indicated for proper estrogen metabolism and symptomatic control in estrogen-dominated health conditions
- Shown to support healthy cellular differentiation of breast and cervical tissues
Proper estrogen metabolism is a crucial factor in maintaining hormone balance in the body and optimizing health outcomes. The initial estrogen detoxification step in the liver creates the metabolites 2-hydroxyestrone (2-OHE1), 4-hydroxyestrone (4-OHE1), and 16-hydroxyestrone (16-OHE1). Although there are many stages of estrogen elimination, this first step is essential because each metabolite has unique actions in the body. The ratio of these compounds has immense health implications.
Indole-3-carbinol (I-3-C) is naturally found in cruciferous vegetables such as broccoli and cauliflower and is well known for its ability to support healthy estrogen metabolism. I-3-C upregulates the production of 2-OHE1, the protective form of estrogen that acts as an estrogen antagonist. 16-OHE1, on the other hand, has potent estrogenic and proliferative effects that antagonize the action of 2-OHE1. Research has repeatedly shown that a higher ratio of 2-OHE1 to 16-OHE1 is protective against disease and desirable for improving symptoms in estrogen-dominant conditions. I-3-C improves this ratio of estrogen metabolites.
Numerous trials have shown that this positive change in estrogen metabolites, following I-3-C supplementation, is beneficial for health outcomes. For example, I-3-C has been shown to improve outcomes in women with cervical disease, with a dose-dependent response for estrogen ratios and regression of CIN severity. Animal studies have also shown that I-3-C can prevent unhealthy cell differentiation in breast tissue.
Not only does I-3-C promote a positive estrogen metabolite ratio, but it also influences the expression of several genes, such as the tumor suppressor gene p53 and BRCA1, which collectively support healthy differentiation of hormone-responsive tissues.
I-3-C is naturally metabolized in the body to provide multiple active compounds, including the predominant metabolite diindolylmethane (D-I-M). Although there is debate as to whether D-I-M or I-3-C is most beneficial as a health supplement, each compound has its benefits. D-I-M is the main metabolite of I-3-C, but it is not the only metabolite. I-3-C provides the body with all active metabolites and remains a well-researched and effective treatment for the proper regulation of estrogen in the body.
Cyto-Matrix I-3-C contains 200 mg of pure indole-3-carbinol in each vegetable capsule, with 120 vegetable capsules per bottle for targeted, continuous hormonal support.