Iron Bisglycinate

- Provides a clinical dose of 45 mg of elemental iron per capsule.
- The highly absorbable form, iron bisglycinate chelate, has greater bioavailability than standard forms.
- Comparable to iron sulfate at ¼ to ½ the same dose of elemental iron
- Bisglycinate iron chelate is significantly better tolerated than commonly used forms, which allows its continued use and improved effectiveness in replenishing iron stores.
- Suitable for vegetarians and vegans
Iron deficiency remains the most common nutrient deficiency and the most common cause of anemia worldwide. Depleted iron stores impair mitochondrial function and cellular respiration even in the absence of anemia, particularly in metabolically active cells, contributing to symptoms ranging from fatigue and exercise intolerance to cognitive and cardiac impairment. In the majority of cases, the primary means of replenishing iron levels is oral iron supplementation, which is preferable to parenteral administration (injections) in the absence of serious symptoms or contraindications.
In contrast, iron bisglycinate chelate, consisting of two glycine molecules chelated with ferrous iron (Fe2+), demonstrated significantly greater bioavailability than standard forms of iron such as ferrous sulfate, ferrous fumarate, and polymaltose iron. This form is much better tolerated, allowing iron levels to be effectively restored using lower doses. For example, at ¼ to ½ the dose of ferrous sulfate, the iron chelate bisglycinate showed similar effects on hemoglobin, ferritin, and other markers of hematologic status in controlled trials, with improved tolerability. It has also been shown to be effective and well-tolerated in various patient populations, including pregnant women and children with celiac disease. 45 mg of elemental iron per capsule, higher than most formulations, is consistent with current recommendations for restoring depleted iron levels in pregnant women, although below the threshold typically associated with adverse effects.