NEM 500mg

- Natural Eggshell Membrane (NEM®) has been clinically proven to reduce joint pain and stiffness due to osteoarthritis.
- Clinically proven to reduce pain and stiffness resulting from moderate-intensity aerobic exercise.
- Improvement in pain, stiffness and flexibility in the days following use.
- NEM provides many nutrients for joints, including glucosamine, chondroitin and type I collagen. One vegetable capsule of NEM per day is the clinically proven dose.
Numerous clinical trials have shown that NEM reduces joint pain and stiffness associated with osteoarthritis, as well as joint pain and stiffness caused by moderate-intensity aerobic exercise. NEM is composed of eggshell membranes (without shell), a natural source of glycosaminoglycans found in cartilage, including dermatan sulfate and chondroitin sulfate, hexosamines such as glucosamine, as well as hyaluronic acid and type I collagen. In vitro and in vivo assays indicate that NEM has multiple mechanisms of action, including inhibition of several pro-inflammatory cytokines associated with inflammation joints, such as interleukin-1 beta (IL-1β) and tumor necrosis factor alpha (TNF-α).
In a randomized, double-blind, placebo-controlled trial, NEM was shown to rapidly reduce pain, stiffness, and discomfort after exercise in healthy postmenopausal women. It has also been shown to reduce urinary levels of C-terminal cross-linked telopeptide of type II collagen (CTX-II), a biomarker of cartilage breakdown, in both healthy people and those with joint diseases. Additionally, controlled clinical trials have shown a reduction in joint pain and stiffness in people with knee osteoarthritis within 10 days of using NEM. Open-label trials have shown persistent improvements in pain and flexibility for multiple joint and connective tissue disorders within 1 week.