SAMe (S-Adenosylmethionine)

- SAMe with improved stability to promote healthy balance of humors and comfort of osteoarthritic joints
SAMe (S-Adenosylmethionine) is a metabolite present in all living cells. It is a donor of methyl groups in over 100 different reactions and contributes to the synthesis, activation and/or metabolism of hormones, neurotransmitters, nucleic acids, phospholipids and proteins. Methyl groups act as a signal in the body, regulating gene expression and cellular function. As demonstrated in over 40 clinical studies, SAMe also promotes mood balance. In a meta-analysis pooling results from 25 controlled clinical trials and 791 subjects, SAMe had a statistically significant positive effect on mood, likely due to its support for the synthesis and activity of monoamine (a neurotransmitter), including dopamine and serotonin. It also promotes healthy protein turnover and maintains healthy phospholipid methylation to support phosphatidylcholine production as well as the integrity and fluidity of cell membranes. Studies suggest that it also supports joint comfort and flexibility in people with osteoarthritis. In a meta-analysis pooling results from 11 studies, SAMe demonstrated statistically significant support of joint function. It is believed to relieve osteoarthritis pain by supporting proteoglycan synthesis and helping to stabilize and protect proteoglycans.