Tudca

- Liver support
- 250 mg of tauroursodeoxycholic acid (TUDCA) and 75 mg of additional choline to optimally support liver health, microbiome balance, metabolism and neurological health.
- 250 mg of TUDCA per capsule to optimally support liver health, microbiome balance, metabolism and neurological health.
- TUDCA is a conjugated bile salt that is important for bile synthesis and for reducing fat accumulation in the liver, but also reduces endoplasmic reticulum stress and thus supports cellular function in nervous tissues and other organ systems.
- 75 mg of choline per capsule, in the form of highly bioavailable choline bitartrate salt, providing a relatively high amount of elemental choline to support neurological function, cognition and liver health through the production of phosphatidylcholine, bile, acetylcholine and betaine.
Bile salts are one of the main components of bile, a fluid essential for the digestion of fats, the absorption of fat-soluble vitamins, the elimination of wastes and the formation of hormones. Bile and bile salts are made by the liver and stored in the gallbladder between meals. A deficiency in bile salts can cause poorly digested fats to pass through the digestive tract, causing flatulence, cramping, loose stools and, ultimately, an increased risk of gallstone formation.
Tauroursodeoxycholic acid, more commonly known as TUDCA, is a conjugated bile salt that may contribute to gallbladder and liver health. Specifically, TUDCA has been shown to be a safe and effective support for patients with primary biliary cholangitis (PBC), a chronic autoimmune disease that causes a buildup of bile in the liver, and it may protect the liver from damage caused by liver cirrhosis due to long-term alcohol consumption. TUDCA was also shown to slow the progression of metabolic dysfunction-associated fatty liver disease (MASLD) in mice fed a high-fat diet by reducing intestinal inflammation, improving intestinal barrier function, decreasing intestinal fat transport, and modulating gut microbiota composition. Another study in mice also showed that TUDCA could potentially hinder the development of gallstones by reducing fat absorption in the intestinal tract.
Although TUDCA's role in liver and gallbladder health may seem more obvious, TUDCA also has a unique mechanism of action outside of biliary support. TUDCA has been shown to relieve endoplasmic reticulum (ER) stress in cells, thereby improving protein folding and cell signaling. TUDCA's ability to reduce endoplasmic reticulum stress extends its potential health benefits beyond liver health to a wide variety of chronic diseases that have demonstrated endoplasmic reticulum stress. Mechanistically, TUDCA also provides cellular protection by better regulating apoptosis.
One of the most important applications of TUDCA's cellular protective role is in the area of ​​neurological health. Animal studies have shown that TUDCA serves as a neuroprotectant against acute injuries such as stroke, as well as chronic neurodegenerative diseases.
TUDCA also shows promise in reversing metabolic disorders caused by excess body fat and malnutrition. Indeed, TUDCA was found to significantly improve insulin sensitivity in liver tissue and muscle. In a study in aged mice, TUDCA reduced hyperinsulinemia and improved glucose regulation by enhancing the liver's ability to break down insulin. Finally, TUDCA also demonstrated protection against cell death in retinitis pigmentosa and defense against renal fibrosis, and even cardioprotective function by reducing scar tissue, cell death and cardiac damage in mouse hearts subjected to increased pressure.
TUDCA from CytoMatrix combines 250 mg of tauroursodeoxycholic acid (TUDCA) and 75 mg of additional choline to optimally support liver health, microbiome balance, metabolism and neurological health. Choline, like TUDCA, is also essential for the production of bile and the elimination of cholesterol by the liver. TUDCA from CytoMatrix provides choline in the form of VitaCholine®, a patented and clinically studied choline bitartrate salt. VitaCholine® provides a relatively high amount of elemental choline, which dissolves quickly and becomes available in the body as free choline, without requiring enzymatic release. VitaCholine® also supports neurological function, cognition and liver health through the production of phosphatidylcholine, bile, acetylcholine and betaine.