Vitamine K2 · 100 mcg

- Provides 100 mcg per serving of vitamin K2 in the form of menaquinone-7 (MK-7)
- MK-7 has the longest half-life of all forms of vitamin K, as well as the best extra-hepatic distribution
- Vitamin K2, in particular MK-7, allows a much lower dosage with significant clinical benefit
- Natto Bean Extract, the richest natural food-based MK-7
- Suitable for vegetarians/vegans
The discovery of vitamin K-dependent (VKD) posttranslational modifications of proteins involved not only in coagulation, but also in bone metabolism, vascular calcification, cell growth regulation, and even ATP production has radically changed the physiological and clinical importance of this enzyme cofactor. VKD cofactor proteins are present almost ubiquitously in various cell types, and modification by γ-carboxylation is necessary for biological activity. Dietary intake of vitamin K is often insufficient and vitamin K is diverted to enzymes essential for short-term survival (e.g. coagulation), leading to suboptimal carboxylation of proteins associated with aging and chronic disease, such as matrix protein Gla, osteocalcin and gas6.
Clinically, lower vitamin K intake has translated into a higher risk of myocardial infarction and stroke, plaque instability, and, more recently, diabetes. Higher intake of vitamin K, particularly K2, has been associated with lower intake from all causes. mortality, coronary heart disease, aortic calcification, and cancer incidence and mortality. Higher intake of MK-7, which has the longest half-life and largest extrahepatic distribution, was associated with lower risk of fracture and greater BMD.